CURRICULUM VITAE OF MICHAEL SEAN REAGAN
Education
1985 B.A. Biology
Department of Biology
St. Olaf College
Northfield, MN 55057
1992 Ph.D. Molecular Genetics
Department of Biochemistry and Molecular Biophysics
Washington University School of Medicine
St. Louis, MO 63110
Advisor: Dr. John E. Majors
Transcriptional control of the GAL1 –10 genes in the yeast S. cerevisiae.
Experience & Appointments
6/04 -present Associate Professor
St. John's University/College of St. Benedict
Collegeville, MN 56321-3000
8/97-6/04 Assistant Professor, St. John’s University Biology Department
9/93 - 7/97 Postdoctoral Fellow
In the lab of Dr. Errol Friedberg
Department of Pathology
The University of Texas Southwestern Medical Center
DNA repair in the yeast S. cerevisiae.
2/93-5/93 Instructor
Biology Department
St. John’s University/ College of St. Benedict
Collegeville, MN 56321-3000
Courses Taught Biochemistry – upper level, 1 semester course
Molecular Genetics – upper level, 1 semester course focusing on gene expression
Concepts of Biology – our two-semester introductory sequence
Symposium: Genes and Society – A full-year course that takes the place of “Freshman English”. I used ethical dilemmas raised by genetics research to teach communication and critical thinking skills.
Human Biology – Nonmajors natural science course
Introduction to Genetic Counseling – a January term (3 weeks) course
Research Interests
We study DNA damage and DNA repair and the effects of DNA damage on transcription using the yeast S. cerevisiae.
Memberships
American Association for the Advancement of Science (AAAS)
Environmental Mutagen Society (EMS)
Coucil on Undergraduate Research (CUR)
Service to the Department and the Schools
Biology Department Assessment Committee ’98- ‘03
Co-developer (with one other) of (unsuccessful) Howard Hughes Medical Institute proposal ‘99
Co-organizer (with one other) of the summer research program at CSB/SJU ‘00
Goldwater Scholarship committee ’98-‘99
CSB/SJU Admissions Committee to study applications of students whose records were marginal or needed special consideration
Organizer of the Schirber lecture ’99 - '06
Faculty Research and Development Committee ’00- ‘03
Faculty Compensation Committee ’03-‘04
Curricular and Strategic Planning Committee '05-'06
Academic Budget and Planning Committee '06-'08 (chair '06-'07)
Publications
* indicates undergraduate student coauthor.
*Shaheen, Z., *Bouska, C., and M.S. Reagan. 2007. The Effect of DNA Ethylation on RNA Polymerase II Transcription in the Yeast Saccharomyces cerevisiae. (Abstract) Environmental and Molecular Mutagenesis 48:580.
M. S. Reagan. 2007. But What is it You Actually Do? (What It’s Really Like Working in a Research Lab) Headwaters: A Faculty Journal 23: 82-90.
M.S. Reagan. 2004. Integrating Research and Teaching Labs with the Module Evolution Approach. CUR Quarterly, 24:165.
*McInnis, M., *O’Neill, G., *Fossum, K., and M.S. Reagan. 2002. Epistatic Analysis of the roles of the RAD27 and POL4 gene products in DNA base excision repair in S. cerevisiae. DNA Repair. 1:311-315.
*Hansen, R.J., Friedberg, E.C., and M.S. Reagan. 2000. Sensitivity of a S. cerevisiae deletion mutant to DNA-damaging agents and in vivo complementation by the human FEN-1 protein. Mutation Research. 461:243-248.
Friedberg, E.C., Feaver, W.J., Huang, W., Reagan, M.S., Reed, S.H., You, Z., Wei, S., Rodriguez, K., Talamantez, J., and A.E. Tomkinson. 1999. The Current Status of Nucleotide Excision Repair in the Yeast Saccharomyces cerevisiae. Advances in DNA Damage and Repair. Disdaroglu and Karakaya (eds.) Plenum Press, New York.
Friedberg, E.C., Feaver, W.J., Huang, W., Reagan, M.S., Ramos, W.A., Rodriguez, K., Reed, S.H., Tomkinson, A.E., Wei, S., You, Z-Y. 1998. Nucleotide Excision Repair in Yeast: Recent Progress and Implications. Nucleic Acids and Molecular Biology. 12:125-139.
Reagan, M.S. and J.E. Majors. 1998. The Chromatin Structure of the GAL1 Promoter Forms Independently of Reb1 Protein. Molecular and General Genetics. 259:142-149.
Reagan, M.S. and E.C. Friedberg. 1997. Recovery of RNA Polymerase II Synthesis Following DNA Damage in Mutants of Saccharomyces cerevisiae Defective in Nucleotide Excision Repair. Nucleic Acids Res. 25:4257-4263.
Iyer, N., M.S. Reagan, K-J. Wu, B. Canagarajah, and E.C. Friedberg. 1996. Interactions involving the human RNA polymerase II transcription/nucleotide excision repair factor TFIIH, the nucleotide excision repair protein XPG and Cockayne syndrome group B protein. Biochemistry 35:2157-2167.
Henning, K.A, L. Li, N. Iyer, L.D. McDaniel, M.S. Reagan, R. Legerski, R.A. Schultz, M. Stefanini, A.R. Lehmann, L.V. Mayne, and E.C. Friedberg. 1995. The Cockayne syndrome group A gene encodes a WD repeat protein that interacts with CSB protein and a subunit of RNA polymerase II TFIIH. Cell 82:555-564.
Reagan, M.S., C. Pittenger, W. Siede, and E.C. Friedberg. 1995. Characterization of a mutant strain deleted for the RAD27 gene of Saccharomyces cerevisiae; a structural homolog of the RAD2 nucleotide excision repair gene. J. Bacteriol. 177:364-371.
Reagan, M.S., C. Pittenger, W.Siede, and E.C. Friedberg. 1995. Characterization of a Saccharomyces cerevisiae strain deleted for the RAD27 gene; a structural homolog of the RAD2 nucleotide excision repair gene. (Abstract) J. Cell. Biochem. Sup. 21A:303.
Bardwell, A.J., L. Bardwell, Z. Wang, W. Siede, M.S. Reagan, A.E. Tomkinson, A.S. Friedberg, C. Pittenger, W.J. Feaver, J. Svejstrup, R.D. Kornberg, and E.C. Friedberg. 1994. Recent insights on DNA repair: the mechanism of damaged nucleotide excision in eukaryotes and its relationship to other cellular processes. (review) Annals N.Y. Acad. Sci. 726:281-291.
Axelrod, J.D., M.S. Reagan, and J. Majors. 1993. GAL4 disrupts a repressing nucleosome during activation of GAL1 transcription in vivo. Genes. Dev. 7:857-869.
*Shaheen, Z., Bouska, C. and M.S. Reagan. April 10-12, 2008. “The Effect of Ethylation on RNA Polymerase II Transcription in the Yeast Saccharomyces cerevisiae”. At National Council of Undergraduate Research National Conference, Salisbury University, Maryland.
*Ward, K.A., *Shaheen, Z. R. and M. S. Reagan. August 6-11, 2006. Effect of ethylation on transcriptional elongation in vivo in the yeast Saccharomyces cerevisiae. At Gordon Research Conference "Mutagensis", Salve Regina College, Rhode Island.
*McInnis, M., *O’Neill, G., *Fossum, K., and M.S. Reagan. July 28-August 2, 2002. Epistatic Analysis of the roles of the RAD27 and POL4 gene products in DNA base excision repair in S. cerevisiae. At Gordon Research Conference “Mutagenesis”, Bates College, Maine.
M.S. Reagan. January 19, 2002. Epistatic Analysis of the roles of the RAD27 and POL4 gene products in DNA base excision repair in S. cerevisiae. Minnesota Area Yeast Meeting, University of Minnesota.
M.S. Reagan. January 13, 2001. The role of the Rad27 (FEN-1) protein in DNA base excision repair. Minnesota Area Yeast Meeting, University of Minnesota.
*Hansen, R.J. and M.S. Reagan. May 31-June 5, 2000. Sensitivity to Alkylating Agents of a Saccharomyces cerevisiae Strain Deleted of the RAD27 Gene, and Complementation by the Human FEN-1 Protein. at “65th Symposium: Biological Responses to DNA Damage.” Cold Spring Harbor Lab, New York.
*Hansen, R.J. and M.S. Reagan. April 6, 2000 “DNA Repair Defects of Saccharomyces cerevisiae Deleted of the RAD27 Gene and Complementation by the Human FEN-1 Protein” at “Undergraduate Research Posters on Capitol Hill”. Washington, D.C.
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